Publications

 
 

2023

Dewachter L*, Brooks A N, Noon K, Cialek C, Clark-ElSayed A, Schalck T, Krishnamurthy N, Versées W, Vranken W, Michiels J*. (2023). Deep mutational scanning of essential bacterial proteins can guide antibiotic development. Nature Communications 14: 241.
doi: 10.1038/s41467-023-35940-3
* Corresponding authors

2022

Dewachter L, Dénéréaz J, Liu X, de Bakker V, Costa C, Baldry M, Sirard J-C, Veening J-W. (2022). Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq. eLife 11:e75607. 
doi: 10.7554/eLife.75607

2021

Dewachter L*, Bollen C*, Wilmaerts D, Louwagie E, Herpels P, Matthay P, Khodaparast L, Khodaparast L, Rousseau F, Schymkowitz J, Michiels J. (2021). The dynamic transition of persistence towards the viable but nonculturable state during stationary phase is driven by protein aggregation. mBio 12:e00703-21. 
doi: 10.1128/mBio.00703-21 
* Equal contribution

Bollen C, Dewachter L*, Michiels J*. (2021). Protein aggregation as a bacterial strategy to survive antibiotic treatment. Front Mol Biosci, 8: 669664.
doi: 10.3389/fmolb.2021.669664
* Equal contribution

2019

Dewachter L, Fauvart M, Michiels J. (2019). Bacterial heterogeneity and antibiotic survival: understanding and combatting persistence and heteroresistance. Molecular Cell 76(2): 255-267.
doi: 10.1016/j.molcel.2019.09.028

Wilmaerts D, Dewachter L, De Loose PJ, Bollen C, Verstraeten N, Michiels J. (2019). HokB monomerization and membrane repolarization control persister awakening. Molecular Cell, 75(5): 1031-1042.e4.
doi: 10.1016/j.molcel.2019.06.015

2018

Dewachter L, Verstraeten N, Fauvart M, Michiels J. (2018). An integrative view of cell cycle control in Escherichia coli. FEMS Microbiology Reviews 42(2): 116-136.
doi: 10.1093/femsre/fuy005

2017

Dewachter L, Verstraeten N, Jennes M, Verbeelen T, Biboy J, Monteyne D, Pérez-Morga D, Verstrepen KJ, Vollmer W, Fauvart M, Michiels J. (2017). A mutant isoform of ObgE causes cell death by interfering with cell division. Frontiers in Microbiology 8: 1193.
doi: 10.3389/fmicb.2017.01193

2016

Dewachter L, Herpels P, Verstraeten N, Fauvart M, Michiels J. (2016). Reactive oxygen species do not contribute to Obg*-mediated programmed cell death. Scientific Reports 6: 33723.
doi: 10.1038/srep33723

2015

Dewachter L, Verstraeten N, Monteyne D, Kint CI, Versées W, Pérez-Morga D, Michiels J, Fauvart M. (2015). A single-amino-acid substitution in Obg activates a new programmed cell death pathway in Escherichia coli. mBio 6(6): e01935-15.
10.1128/mBio.01935-15

Verstraeten N, Knapen WJ, Kint CI, Liebens V, Van den Bergh B, Dewachter L, Michiels JE, Fu Q, David CC, Fierro AC, Marchal K, Beirlant J, Versées W, Hofkens J, Jansen M, Fauvart M, Michiels J. (2015). Obg and membrane depolarization are part of a microbial bet-hedging strategy that leads to antibiotic tolerance. Molecular Cell, 59(1): 9-21.
doi: 10.1016/j.molcel.2015.05.011

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